We just got back from another Vegas trip. My partner and I are not really the nightlife/gambling type-we were in Vegas at the end of a hiking trip to Utah-so it was nice to be in a place where you can choose how much you want to immerse yourself in it, not have it forced upon you. Experience but you can avoid the chaos of that entirely if you want to, and you don't have to go through the casino to get to the hotel. The hotel is very close to the Fremont St. Despite that I would certainly stay at Main Street again.
We preferred the one at Luxor, particularly their salad bar. Not bad, but just not that great, and the seafood was the least good part. We had the seafood buffet on Friday night which was not as good as we expected-I had read in our guidebook that the buffet is supposed to be really excellent but it must have fallen off somewhat. We arrived too late to get the non-smoking room I had requested at reservation (if they tend to run out why not designate more of them?.) but we were told that if there was a problem they would send up a smoke extractor machine, and as it turned out the room wasn't smoky at all. Rooms are large, clean, comfortable, quiet the decor in the lobby is distinctive and appealing.
If you want to stay downtown this is definitely the place to go in my opinion.